Born 1941. Education: Eötvös Loránd University, Budapest, Chemistry major

M.Sc., 1965; Ph.D., 1967 (Eötvös Loránd University)

C.Sc., 1981, D.Sc., 1990, Member of the Hungarian Academy of Sciences, 1998-

Employment: 1965- Department of Organic Chemistry, from 1991 Professor, Head of the Department (1993-2006)

Head of the Laboratory for chiroptical structure analysis

Teaching experience

1965-85: Practical courses in Organic Chemistry for Chemistry teacher trainees, Biology and Chemistry major students
1985-90: Basic Organic Chemistry for Chemistry major students and teacher trainees
1990-: Natural Products Chemistry for Chemistry major students, Stereochemistry and Chiroptical Spectroscopy and Biomolecular Chemistry (Structural Biology) optional courses for Chemistry teachers and Chem. major students

Research interests

• Chiroptical spectroscopy (determination of the absolute configuration or absolute conformation by VCD and theoretical calculation).
• Conformational analysis of linear and cyclic peptides by CD (ECD and VCD), FTIR and NMR spectroscopy.
• Spectroscopic studies on chiral crown ethers and their complexes with aralkylammonium ions and cations.
• Spectroscopic studies on cation-peptide and cation-protein interactions.
• Synthesis of fluorescence-labelled cell-penetrating peptides (CPPs). Spectroscopic and biological studies on CCP- oligonucleotide conjugates.

Publications

More than 170 papers, mostly in English in international journals (>1800 independent citations), five book chapters in English, four books in Hungarian

Five selected publications

1. Hollósi, M., Ürge, L., Perczel, A., Kajtár, J., Teplán, I., Ötvös, L. Jr., Fasman, G.D., Metal ion-induced conformational changes of phosphorylated fragments of human neurofilament (NF-M) protein., J. Mol. Biol. 223 673-682 (1992) [abstract]



2. Hollósi, M, Shen, Z.M., Perczel, A., Fasman, G.D., Stable intrachain and interchain complexes of neurofilament peptides: a putative link between Al3+ and Alzheimer disease., Proc. Natl. Acad. Sci. USA 91 4902-4906 (1994) [abstract]



3. Vass, E., Hollósi, M., Besson, F. Buchet, R., Vibrational spectroscopic detection of beta and gamma turns in synthetic and natural peptides and proteins., Chem. Rev. 103 1917-1954 (2003) [abstract]



4. Farkas, V., Vass, E., Hanssens, I., Majer, Zs., Hollósi, M.: Cyclic peptide models of the Ca2+-binding loop of a-lactalbumin, Bioorg. Med. Chem. 13 5310-5320 (2005) [abstract]



5. Martinek, T.A., Mándity, I.M., Fülöp, L., Tóth, G.K., Vass, E., Hollósi, M., Forró, E., Fülöp, F.: Effects of the alternating backbone configuration on the secondary structure and self-assembly of beta-peptides, J. Am. Chem. Soc. 128 13539-13544 (2006) [abstract]