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Short CV:
Place and date of birth:
- Berlin (Germany), 30. May 1969.
Education:
- 1990-1995: Chemistry, State University of Uzhgorod, Uzhgorod, Ukraine
- 1995: MSc Degree in Chemistry, State University of Uzhgorod
- 1996-1999: PhD School, Institute of Chemistry, Faculty of Sciences, Eötvös University, Budapest, Hungary
- 2003: Ph.D. thesis entitled "Synthesis and chemotactic investigation of oligopeptides containing XWS motifs"
Place of work:
- Eötvös Loránd University Department of Organic Chemistry, Budapest, Hungary
Positions held:
- 1996-2002: Engineer, Eötvös Loránd University, Department of Organic Chemistry
- 2002-2003: Research assistant, Eötvös Loránd University, Department of Organic Chemistry
- 2004-2006: Research Associate, Research Group for Peptide Chemistry, Hungarian Academy of Sciences
- 2007-present: Assistant Professor, Eötvös Loránd University, Institute of Chemistry
Teaching:
- 1999-present Practical courses in Organic Chemistry for Chemistry teachers and Biology Teacher trainees
Research activities and interests:
- solid and solution phase peptide synthesis; application of combinatorial methods (split synthesis, multiple synthesis)
- preparation of peptide epitopes; cyclopeptides, chemotactic peptides, cell penetrating peptides;
- labelling peptides with fluorescent compounds;
- protein expression , purification,
- peptide spectroscopy, bioorganic chemistry, mass spectrometry
- tryptophan-mediated photolysis of disulfide bridges in proteins and peptides
Experience:
- In chemistry: RP-HPLC, CD (circular dichroism), mass spectrometry (ESI-MS)
- In biology: ELISA technique, SDS-PAGE, Western blot, PCR, protein expression and purification
Publications:
- 10 journal papers
- 11 conference proceedings
5 selected publications:
- Illyés, E., Hudecz, F., Kőhidai, L., Láng, O., Szabó, P. and Sebestyén, F. (2002). Synthesis of oligopeptides with SXWS sequence and their chemotactic effect on a ciliated protozoan Tetrahymena pyriformis. J. Peptide Sci. 8, 13-22.
- Illyés, E., Bősze, Sz., Láng, O., Kőhidai, L., Sebestyén , F. and Hudecz, F. (2002): A new class of chemotactic peptides containing EWS motif: a minireview. Chimica Oggi 20, 55-61.
- Van de Walle, G., Vanhoorelbeke, K., Majer, Zs., Illyés, E., Baert, J., Pareyn, I. and Deckmyn H. (2005): Two functional active conformations of the integrin α2β1, depending on activation condition and cell type J. Biol. Chem., 280, 44, 36873-36882.
- Vanhooren, A., Illyés, E., Majer, Zs., Hanssens, I. (2006): Fluorescence contributions of individual Trp-residues in goat α-lactalbumin. BBA Proteins and Proteomics, 1764, 1586-1591.
- Laczkó, I., Váró, G., Bottka, S., Bálint, Z., Illyés, E., Vass, E., Bertrand, J.-R., Malvy, C., Hollósi, M. (2006): N-terminal acylation of the SV40 nuclear localization signal peptide enhances its oligonucleotide binding and membrane translocation efficiencies Archives of Biochemistry and Biophysics 454, 2, 146-154.
Study trips:
- 1999: 1 month, Département d'Ingénierie et d'Etudes des Protéines, CEA Centre d'Etudes de Saclay, Gif-sur-Yvette, France (Claudio Vita)
- 2001: 1 month, Département d'Ingénierie et d'Etudes des Protéines, CEA Centre d'Etudes de Saclay, Gif-sur-Yvette, France (Claudio Vita)
- 2005-2006: 8 months, Katholic Universitet of Leuven Interdisciplinary Research Center Campus Kortrijk, Kortijk Belgium in Protein biophysics laboratory. (Flamish-Hungarian bilaterial TeT project)
Knowledge of Foreign Languages:
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