Short CV:
Born: 1959.
MSc: 1985, PhD: 1988
CSc: 1992, DSc: 1998
CMHAS: 2010
Employment: 1993-98: associate research professor, 1998-2001: research professor, 2001: full professor, 2007: head of the Dept. of Organic Chemistry at the Institute of Chemistry, Eötvös Loránd University
Teaching experience
- 1985-94 Organic chemistry laboratory courses
- 1994- Structural investigation of peptides and proteins (optional course)
- 1996-2001 Organic chemistry laboratory courses
- 1997- NMR pulse sequences in structure determination (optional course)
- 2001- Organic chemistry for biologists (lectures)
- 2003- Theoretical organic chemistry (lectures)
- 2008- Biological chemistry (lectures)
Research interests:
- Synthesis of peptides on solid phase and using biotechnology
- Spectroscopic analysis (CD, NMR) of bioactive peptides
- Structure and stability of α- and β-peptides, their nanofibril-forming and aggregation potency
- Protein bioNMR: structure, dynamics and function in glubular and disordered (IUP) systems
- Mapping protein-ligend interactions. Structural investigations on biologically important systems.
Structural Chemistry and Biology Laboratory
ELTE-MHAS protein modelling group
Publications:
More than 170 papers in international journals with over 2100 independent citations,
three book chapters, two reviews and one book (in Hungarian)
Awards:
Pro Scientia gold medal 1993 and 1995 (form the Hungarian Acad. of Sci.),
Zemplén Géza award 1996 ( form the Hungarian Acad. of Sci.),
Scientific award (1st price) in 1997 (form the Faculty of Science L. Eötvös. Univ.), Széchényi Professor form 1998-,
Széchényi Professor form 1998-2002,
Scientist of the year, Sanofi-Synthelabo, 2004
Five selected publications:
- Péter Hudáky, Pál Stráner, Viktor Farkas, Györgyi Váradi, Gábor Tóth, András Perczel:
Cooperation between a salt bridge and the hydrophobic core triggers fold stabilization in a Trp-cage miniprotein
Biochemistry (2008) 47:1007-1016.
[abstract]
-
András Perczel, Péter Hudáky and Villő Pálfi:
Dead-end street of protein folding: thermodynamic rationale of amyloid fibril formation
J. Am. Chem. Soc. (2007) 129:14959-14965
[abstract]
-
Charles D. Blundell, David J. Mahoney, Martin R. Cordell, Andrew Almond, Jan D. Kahmann, András Perczel, Jonathan D. Taylor, Iain D. Campbell
and Anthony J. Day:
Determining the molecular basis for the pH-dependent interaction between the Link module of human TSG-6 and hyaluronan
J. Biol. Chem. (2007) 282:12976-12988.
[abstract]
-
Gábor Pohl, Tamás Beke, János Borbély and András Perczel:
Prediction of folding preference of 10kDa silk-like proteins using a lego-approach and ab initio calculations
J. Am. Chem. Soc. (2006) 128:14548-14559
[abstract]
-
Tamás Beke, Imre G. Csizmadia and András Perczel:
Theoretical study on tertiary structural elements of β-peptides: Nanotubes formed from parallel-sheet-derived assemblies of β-peptides
J. Am. Chem. Soc. (2006) 128:5158-5167.
[abstract]
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