Furka, Á., Sebestyén, F., Asgedom, M., Dibó,
G. General method for rapid synthesis of multicomponent peptide mixtures
(1991). Int. J. Peptide Protein Res. 37, 487.
ABSTRACT:
A method is suggested for the synthesis of multicomponent peptide mixtures.
The method is a solid phase synthesis modified inorder to give a closely
equimolar mixture of peptides with predetermined sequences. The main point
of modification is thatbefore every coupling cycle the resin is divided
into equal parts and each portion is coupled with a different amino acid.
The portions are mixed and before the next coupling cycle the resin is
again distributed into equal portions. The method is illustrated by the
synthesis of a mixture of 27 tetrapeptides and 180 pentapeptides.
Back to main page